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8.18 PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal

T Dumontet , I Sahut-Barnola , A Septier , N Montanier , I Plotton , F Roucher-Boulez , V Ducros , AM Lefrançois-Martinez , JC Pointud , M Zubair , KI Morohashi , DT Breault , P Val , A Martinez

To read the full abstract: JCI Insight. 2018;3(2). pii: 98394The (human) adrenal cortex undergoes massive changes in structure and function from fetal to postnatal life, with the first consisting of a small outer definitive zone and a larger inner fetal zone, and the latter finally consisting of three distinct layers, namely the zona glomerulosa (ZG), fasciculata (ZF) and reticularis (ZR). Ho...

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ey0020.6-1 | Mechanism of the Year | ESPEYB20

6.1. Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice

D Dufour , T Dumontet , I Sahut-Barnola , A Carusi , M Onzon , E Pussard , JJ Wilmouth , J Olabe , C Lucas , A Levasseur , C Damon-Soubeyrand , JC Pointud , F Roucher-Boulez , I Tauveron , G Bossis , ET Yeh , DT Breault , P Val , AM Lefrancois-Martinez , A Martinez

Brief summary: This study investigates the role of SUMOylation in adrenal development and functionThe murine adrenal cortex is a constantly self-renewed endocrine organ composed of concentric zones, including the outermost zona glomerulosa (zG) producing mineralocorticoids and the innermost zona fasciculata (zF) producing glucocorticoids. According to the centripetal migration model occurring during postnatal development, progenitor cell populations loca...

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ESPE Yearbook of Paediatric Endocrinology

8.18 PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal

6.1. Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice

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